The increasing prevalence of antibiotic-resistant bacteria poses a significant threat to global human health. Developing new antibiotics is a slow and costly process, so an alternative solution is to explore the potential of phages, which are natural predators of bacteria. Our goal is to investigate phage genomes as a potential source of new antibacterial agents. Once we have identified promising genes, we will validate their efficacy and produce them as standalone therapeutics.
The project consists of two parts: computational and experimental. The computational part is expected to be completed within 6-12 months, depending on the time allocation and skills of the contributors. The experimental part may take up to two years, depending on the findings.
Most related reference and related literature:
Reference 1: https://doi.org/10.1080/19490976.2018.1455790
Reference 2: https://doi.org/10.1038/s41587-022-01226-0